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THE SCIENCE OF STRUM
30 ingredients. Four longevity pathways. One honest scoop.
Strum is a comprehensive daily longevity blend formulated for the way women's bodies actually age. Below is every key ingredient - the dose we use, how it works, and the peer-reviewed research behind it. We also tell you, plainly, where our doses sit relative to the studies.
Cellular longevity
Gut & immune
Metabolic balance
Daily vitality
HOW IT FITS TOGETHER
A foundation, not a single hero ingredient
Most supplements do one thing. Strum is built around four interconnected pathways that decline together as women age - and supports each one daily with research-backed compounds.
HOW IT FITS TOGETHER
A foundation, not a single hero ingredient
Most supplements do one thing. Strum is built around four interconnected pathways that decline together as women age - and supports each one daily with research-backed compounds.
🧬
Cellular Longevity
NAD⁺, sirtuin and autophagy pathways that govern how cells produce energy and repair themselves.
🌿
Gut & Immune
The gut barrier and microbiome — the foundation of immunity, nutrient absorption and inflammation.
⚖️
Metabolic Balance
Blood-sugar handling and mitochondrial efficiency that drive steady energy and healthy weight.
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Daily Vitality
Antioxidant defense plus the vitamins and minerals women are most likely to fall short on.
Cellular Longevity
As we age, levels of NAD⁺ — the molecule cells use to make energy and run repair — fall, while worn-out 'senescent' cells accumulate. These ingredients support the body's own renewal machinery.
NMN
125 mg
NAD⁺ PRECURSOR
Nicotinamide mononucleotide is a direct building block for NAD⁺, the coenzyme that powers cellular energy production and DNA repair and naturally declines with age.
What the research shows: In randomized human trials, oral NMN was safe and reliably raised blood NAD⁺ levels, with reviews reporting improvements in physical performance and insulin sensitivity in older adults.
Dose transparency: Many NMN trials use 250 mg+ per day. Strum's 125 mg is a foundational daily dose that contributes to overall NAD⁺ support alongside the rest of the cellular stack.
Trans-Resveratrol
100 mg
SIRTUIN-ACTIVATING POLYPHENOL
A polyphenol that engages sirtuin longevity pathways and acts as an antioxidant. Often paired with NAD⁺ precursors because the two pathways work together.
What the research shows: An 8-week randomized, placebo-controlled trial found trans-resveratrol (75 mg/day) reduced visible signs of skin aging in women over 40; other RCTs report metabolic and vascular benefits.
Dose transparency: Strum's 100 mg meets or exceeds the 75 mg dose used in the women's skin-aging trial.
Fisetin
50 mg
SENOTHERAPEUTIC FLAVONOID
A plant flavonoid studied for its ability to help clear senescent ("zombie") cells and for broad antioxidant activity.
What the research shows: In preclinical work fisetin was the most potent senolytic among ten flavonoids tested, extending health and lifespan in animal models; human senolytic trials are ongoing.
Dose transparency: Experimental "senolytic" protocols use short, very high pulse doses. Strum's 50 mg is a steady daily antioxidant flavonoid dose — not a senolytic pulse.
PQQ
5 mg
MITOCHONDRIAL SUPPORT
Pyrroloquinoline quinone supports the creation of new mitochondria (mitochondrial biogenesis) via the PGC-1α / SIRT1 pathway and provides antioxidant protection.
What the research shows: Mechanistic studies show PQQ stimulates mitochondrial biogenesis; human supplementation has been reported to improve antioxidant capacity and markers of mitochondrial function.
Dose transparency: Human studies often use ~20 mg; Strum's 5 mg contributes to the cellular-energy stack as part of a daily foundation.
Spermidine
2 mg
AUTOPHAGY INDUCER
A naturally occurring polyamine that triggers autophagy — the cellular "clean-up" process that recycles damaged components and declines with age.
What the research shows: A randomized, placebo-controlled trial found spermidine supplementation safe and well tolerated in older adults, with early signals for memory and cognition.
Dose transparency: Strum's 2 mg is consistent with the dietary supplementation doses used in cognition studies.
Gut & Immune Foundation
Roughly 70% of the immune system lives in the gut. A strong gut barrier and a well-fed microbiome underpin immunity, nutrient absorption and inflammation control.
Bovine Colostrum
1,000 mg
GUT BARRIER & IMMUNITY
Grass-fed colostrum delivers immunoglobulins, lactoferrin and growth factors that help maintain the intestinal lining and support immune defense.
What the research shows: Randomized controlled trials report that bovine colostrum reduces intestinal permeability ('leaky gut') and supports immune responsiveness, particularly under physical stress.
Dose transparency: Some clinical trials use up to 20 g/day. Strum's 1 g is a daily maintenance dose within a broader gut-support blend.
Acacia Fiber
1,750 mg
PREBIOTIC FIBER
A gentle soluble fiber (gum acacia) that feeds beneficial bacteria, especially Bifidobacteria, and is well tolerated without the bloating common to other prebiotics.
What the research shows: Human studies show acacia gum is bifidogenic — increasing beneficial gut bacteria — with high digestive tolerance.
Dose transparency: Prebiotic studies often use 10–15 g/day. Strum's 1.75 g works alongside Fibersol-2 and L-glutamine as part of a daily fiber-and-gut blend, not a standalone fiber dose.
Also in this pathway: L-Glutamine (fuel for intestinal cells) and Fibersol-2 (a soluble prebiotic fiber) round out daily gut-barrier and microbiome support.
Metabolic Balance
Steady blood sugar and efficient mitochondria are the difference between all-day energy and the afternoon crash. These compounds support healthy glucose handling and metabolism.
Dihydroberberine
50 mg
GLUCOSE & AMPK SUPPORT
A more absorbable form of berberine that activates AMPK — a master switch for energy metabolism — to support healthy blood-sugar handling.
What the research shows: A randomized crossover trial found low-dose dihydroberberine raises plasma berberine far more efficiently than standard berberine; a meta-analysis of 46 RCTs supports berberine's role in glucose control.
Dose transparency: Because dihydroberberine is far more bioavailable, 50 mg punches above an equivalent dose of ordinary berberine.
Quercetin
100 mg
ANTIOXIDANT POLYPHENOL
A flavonoid with antioxidant activity that complements fisetin and resveratrol and supports vascular and cardiometabolic health.
What the research shows: A meta-analysis of randomized trials found quercetin can lower blood pressure, with the clearest effects at higher daily doses.
Dose transparency: Blood-pressure effects are strongest above 500 mg/day. Strum's 100 mg serves primarily as a daily antioxidant flavonoid alongside the other polyphenols.
Also in this pathway: Magnesium and Taurine act as metabolic cofactors supporting energy production and cardiovascular health.
What the research shows: A systematic review and meta-analysis found oral astaxanthin significantly improved skin elasticity versus placebo; RCTs typically use 4–12 mg/day.
Dose transparency: Strum's 4 mg sits at the bottom of the clinically studied 4–12 mg range.
What the research shows: Randomized, placebo-controlled trials report MSM improves joint comfort and quality of life.
Dose transparency: Joint trials commonly use 1,500–3,000 mg. Strum's 500 mg contributes daily sulfur as part of the vitality blend rather than a therapeutic joint dose.
Also in this pathway, at meaningful daily levels: Vitamin C 250 mg, Vitamin D3 50 mcg, Vitamin E, Vitamin K2 100 mcg, Vitamin B6, Vitamin B12, Zinc and Selenium 70 mcg - foundational micronutrients for energy, immunity and skin.
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Cellular Longevity
NAD⁺, sirtuin and autophagy pathways that govern how cells produce energy and repair themselves.
NMN
125 mg
NAD⁺ PRECURSOR
Direct building block for NAD⁺, a vital coenzyme that declines with age. Supports cellular energy production, DNA repair, and sirtuin activation for longevity pathways.
Research: RCTs show oral NMN safely raises blood NAD⁺ and improves physical performance and insulin sensitivity in older adults.1, 2
Dose note: Many trials use 250 mg+. Strum's 125 mg is a foundational daily dose alongside the rest of the cellular stack.
Trans-Resveratrol
100 mg
SIRTUIN-ACTIVATING POLYPHENOL
Engages sirtuin longevity pathways and acts as an antioxidant. Pairs synergistically with NMN.
Research: An 8-week RCT found trans-resveratrol (75 mg/day) reduced visible skin aging in women over 40.3, 4
Dose note: Strum's 100 mg meets or exceeds the 75 mg dose used in the women's skin-aging trial.
Fisetin
50 mg
SENOTHERAPEUTIC FLAVONOID
Studied for its ability to help clear senescent ('zombie') cells and for broad antioxidant activity.
Research: Preclinical work found fisetin the most potent senolytic among ten flavonoids; human trials ongoing.5
Dose note: Strum's 50 mg is a daily antioxidant dose — not a senolytic pulse protocol.
PQQ
5 mg
MITOCHONDRIAL SUPPORT
Supports the creation of new mitochondria via the PGC-1α / SIRT1 pathway.
Research: Studies show PQQ stimulates mitochondrial biogenesis and improves antioxidant capacity.6
Dose note: Human studies often use ~20 mg; Strum's 5 mg contributes as part of a daily cellular stack.
Spermidine
2 mg
AUTOPHAGY INDUCER
A naturally occurring polyamine that triggers autophagy — the cellular 'clean-up' process.
Research: An RCT found spermidine safe and well tolerated in older adults, with early signals for cognition.7
Dose note: Strum's 2 mg is consistent with dietary supplementation doses used in cognition studies.
🌿
Gut & Immune
The gut barrier and microbiome — the foundation of immunity, nutrient absorption and inflammation.
Bovine Colostrum
1,000 mg
Gut Barrier & Immunity
Grass-fed colostrum delivers immunoglobulins, lactoferrin and growth factors that help maintain the intestinal lining.
Research: RCTs report bovine colostrum reduces intestinal permeability and supports immune responsiveness under physical stress.8, 9
Dose note: Some trials use up to 20 g/day. Strum's 1 g is a daily maintenance dose within a broader gut-support blend.
Acacia Fiber
1,750 mg
Prebiotic Fiber
A gentle soluble fiber that feeds beneficial bacteria, especially Bifidobacteria, without bloating.
Research: Human studies show acacia gum is bifidogenic — increasing beneficial gut bacteria — with high digestive tolerance.10
Dose note: Prebiotic studies often use 10–15 g/day. Strum's 1.75 g works alongside Fibersol-2 and L-glutamine as part of a daily blend.
Also in this pathway: L-Glutamine (fuel for intestinal cells) and Fibersol-2 (a soluble prebiotic fiber).
⚖️
Metabolic Balance
Blood-sugar handling and mitochondrial efficiency that drive steady energy and healthy weight.
Dihydroberberine
50 mg
Glucose & AMPK Support
A more absorbable form of berberine that activates AMPK — a master switch for energy metabolism.
Research: A crossover trial found dihydroberberine raises plasma berberine far more efficiently than standard berberine; a meta-analysis of 46 RCTs supports berberine's role in glucose control.11
Dose note: Because dihydroberberine is far more bioavailable, 50 mg punches above an equivalent dose of ordinary berberine.
Quercetin
100 mg
Antioxidant Polyphenol
A flavonoid that complements fisetin and resveratrol and supports vascular and cardiometabolic health.
Research: A meta-analysis of RCTs found quercetin can lower blood pressure, with clearest effects at higher daily doses.12
Dose note: Blood-pressure effects are strongest above 500 mg/day. Strum's 100 mg serves as a daily antioxidant flavonoid alongside the other polyphenols.
Also in this pathway: Magnesium and Taurine act as metabolic cofactors supporting energy production and cardiovascular health.
✨
Daily Vitality
Antioxidant defense plus the vitamins and minerals women are most likely to fall short on.
Astaxanthin
4 mg
Skin & Antioxidant Carotenoid
One of nature's most potent antioxidant carotenoids, studied for skin and cellular protection.
One of nature's most potent antioxidant carotenoids, studied for skin and cellular protection.13
Dose note: Strum's 4 mg sits at the bottom of the clinically studied 4–12 mg range.
MSM
500 mg
Sulfur for Joints & Tissue
Methylsulfonylmethane supplies bioavailable sulfur, a raw material for connective tissue.
Research: Randomized, placebo-controlled trials report MSM improves joint comfort and quality of life.14
Dose note: Blood-pressure effects are strongest above 500 mg/day. Strum's 100 mg serves as a daily antioxidant flavonoid alongside the other polyphenols.
Also at meaningful daily levels: Vitamin C 250 mg, Vitamin D3 50 mcg, Vitamin E, Vitamin K2 100 mcg, Vitamin B6, Vitamin B12, Zinc and Selenium 70 mcg.
FULL TRANSPARENCY
Supplement Facts
Nothing hidden, no proprietary blends. Here is exactly what's in every 8 g scoop.
Supplement Facts
Serving Size: 1 Scoop (8g) · Servings Per Container: 30
INGREDIENT
AMOUNT
Bovine Colostrum Powder
1,000 mg
Acacia Fiber (Organic)
1,750 mg
L-Glycine
1,500 mg
Taurine
1,000 mg
Fibersol-2
400 mg
L-Glutamine
400 mg
MSM
500 mg
Vitamin C
250 mg
NMN (Nicotinamide Mononucleotide)
125 mg
Trans-Resveratrol
100 mg
Quercetin
100 mg
Alcolec H2O (Sunflower Lecithin)
60 mg
Fisetin
50 mg
Dihydroberberine
50 mg
Magnesium (as Bisglycinate Chelate)
50 mg
Stevia Leaf Extract (Reb A)
30 mg
Ginger Root Extract
25 mg
Vitamin B6
5 mg
Zinc (as Bisglycinate Chelate)
5 mg
Astaxanthin
4 mg
Spermidine
2 mg
Piperine
2 mg
Vitamin D3
50 mcg
Vitamin K2 (MK-7)
100 mcg
Vitamin B12
24 mcg
Selenium
70 mcg
Vitamin E
15 mg
PQQ (Disodium Salt)
5 mg
Other Ingredients: Natural Flavor, Sea Salt.
Contains: Dairy
OUR APPROACH
Why we dose the way we do
Strum is a comprehensive daily foundation, not a mega-dose of any single compound. Stacking 30 evidence-based ingredients into one 8 g scoop means each is dosed to work as part of a system — and to be taken every day, safely, for years.
Some ingredients (resveratrol, astaxanthin, spermidine, dihydroberberine) sit within or above their studied ranges. Others (colostrum, acacia, MSM, quercetin, NMN) are dosed below standalone clinical levels and are designed to contribute to a daily baseline rather than replace a targeted therapeutic dose. We'd rather tell you that than imply otherwise.
✓
Honest framing. We link the research on each ingredient's mechanism — not claims that Strum's exact dose was proven in a trial.
✓
Synergy over single heroes. NAD⁺ precursors, sirtuin activators and antioxidants are studied together because the pathways interact.
✓
Built for daily use. Doses are chosen for long-term, everyday safety and tolerability.
✓
Third-party tested. Every batch is verified for purity and potency, NSF Certified, made in an FDA-registered facility.
One scoop. 30 ingredients. The science, simplified.
Start your daily longevity ritual — and get 42% off your first order.
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THE EVIDENCE
References
1
Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood NAD⁺ levels in healthy subjects.
2
Improved physical performance parameters in patients taking NMN: a systematic review of randomized controlled trials.
3
Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
4
The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: a pilot RCT.
5
Fisetin is a senotherapeutic that extends health and lifespan.
6
Pyrroloquinoline Quinone (PQQ): its impact on human health and potential benefits.
7
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
8
The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial.
9
Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: a randomized, double-blind, placebo-controlled study.
10
Acacia gum is a bifidogenic dietary fibre with high digestive tolerance in healthy humans.
11
Absorption kinetics of berberine and dihydroberberine and their impact on glycemia: a randomized, controlled, crossover pilot trial.
12
Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials (J Am Heart Assoc).
13
Systematic review and meta-analysis on the effects of astaxanthin on human skin ageing.
14
Methylsulfonylmethane improves knee quality of life in participants with mild knee pain: a randomized, double-blind, placebo-controlled trial.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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